9-Nights Tailor Made Bolivia: Lake Titicaca & the Uyuni Salt Flats - Luxury Tailor Made Travel from $5,090

This attractive large city is Bolivia's richest—you'll see expensive cars and luxury merchandise for sale (and plenty of affordable arts and crafts as well). The people of the city and the department (Santa Cruz), known as Cambas, are very proud of their success. By any measure, the Santa Cruz region is the country's wealthiest, and the city is considered the country's most progressive. It is also among the fastest growing, with a population roughly equal to La Paz. There are many Mennonites and Japanese immigrants to the east who have been credited with teaching the local farmers more productive techniques.

This rich agricultural area once benefited those engaged in illegal activities: Santa Cruz was a banking center for the Colombian-Bolivian cocaine trade in the late 1970s and early 1980s, although the region no longer produces cocaine.

See the Basilica Menor de San Lorenzo (visited by the late Pope John Paul in 1988) and its museum (rare ecclesiastical garments and colonial-era silver vessels), the zoo and the Casa de la Cultura Museum (native crafts and art). Relax in Arenal Park (which has an interesting Ethno-Folkloric Museum) or the central plaza (Plaza 24 de Septiembre). Until very recently, three-toed sloths could be seen in the eucalyptus trees that shade the plaza.

Day trips can be made to the pre-Incan ruins at Samaipata. A wonderful five-day excursion to the region east of Santa Cruz called the Chiquitania is also a highlight. There the gorgeous colonial lost-in-time towns of San Xavier, Concepcion, and San Jose de Chiquitos and others have restored churches that date from the Jesuit missions of the late 1600s. There is also the aquatic wonderland of the Pantanal to explore, and the border with Brazil is nearby.

For local entertainment, the Rio Pirai and its adjacent recreation area 10 minutes from the city center is the place to go on weekends. The atmosphere along this shallow river is that of a beach party. Buying food from kiosks, cruising the beach and racing dune buggies are all part of the fun. To really be included, however, you absolutely need to go with a native of Santa Cruz. Santa Cruz is 350 mi/550 km southeast of La Paz.

The 16th-century silver-mining town of Potosi claims to be the world's highest city (15,380 ft/4,690 m). It merits at least a 24-hour stay.

Visit the Casa Nacional de Moneda, or mint. Take a look at the jarring entryway carving of a grinning Bacchus—which must be seen to be believed. Take note of the way the mint itself was constructed—some of its beams, made of a hardwood called quebracha, were hand-carried from the Gran Chaco region, more than 250 mi/400 km away.

Allow time to walk the narrow, winding streets and look at the beautiful colonial buildings. You can take a bus trip to the San Ildefonso Lake (an artificial lake built for silver mining) or to one of the nearby mines. You can even try your luck at the once-fabulous Cerro Rico, the largest silver mine in the world—nearly the entire mountain was found to be pure silver—and responsible for much of colonial-era Spain's enormous wealth. But take note: The cooperative-run mines are squalid Dickensian nightmares—miners work in dank, muddy corridors filled with noxious gases. Wear your worst clothes for the trip and bring a small something for the workers who toil there.
Tours can be arranged from Potosi to the Uyuni salt pans. 50 mi/80 km southwest of Sucre.

The country's constitutional capital, Sucre is located in a scenic valley at an elevation of 8,900 ft/2,700 m. It is home to the Supreme Court of Bolivia and three universities.

Sucre is one of the most relaxing and pleasant cities in Bolivia—the architecture has a European flavor, and the region has a delightful climate. It offers several interesting sights, among them the Cathedral and Chapel of Guadalupe, the Casa de la Libertad (colonial artifacts related to Bolivian independence), university museums and Immaculada Convent (shop there for handicrafts). In fact, the entire city is eye candy: By law, all of the houses and structures in the central area must be painted solid white, and the contrast of colorfully clad native peoples against a pure white backdrop is a sight to be seen. Also see the ruins of Calle-Calle in the Zudanez neighborhood.

But the real highlight is a day trip to nearby Tarabuco for the colorful Sunday carnival. Amerindians from throughout the area go to town to dance and have a good time. The clothing and singing are fabulous. Sucre is 260 mi/420 km southeast of La Paz.